Alexander Zverev stunned World number two Novak Djokovic 6-4, 6-3 in the summit clash in Rome to put himself firmly in the frame as a potential champion in the second major of the season.
Indian tennis Rohan Bopanna and his Uruguayan partner Pablo Cuevas will aim to book their place in the semi-finals of the Italian Open.
Andy Murray, the defending champion, crashed out to Fognini 2-6, 4-6 in just over 90 minutes.